Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 6/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598543 | 0.86 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8598600 | 0.86 | THRB (0.42) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8598985 | 0.85 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8602001 | 0.85 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8600059 | 0.84 | PTGES (0.40) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8595606 | 0.84 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8598511 | 0.83 | PTGES (0.41) | PTGESLMNAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL8601221 | 0.83 | HPGD (0.46) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8602720 | 0.80 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPTGES | |
| SCHEMBL8602102 | 0.80 | TYK2 (0.44) | PDE4BPDE4APDE4CPDE4DPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |