Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602151 | 1.00 | POLB (0.49) | POLBLMNACTSDKDM4ENLRP3 | |
| SCHEMBL8416857 | 0.91 | NLRP3 (0.45) | POLBLMNACTSDNLRP3KMT2A | |
| SCHEMBL8416853 | 0.91 | NLRP3 (0.45) | POLBLMNACTSDNLRP3KMT2A | |
| SCHEMBL8603237 | 0.85 | POLB (0.43) | POLBLMNAKDM4EKMT2APDE11A | |
| SCHEMBL8603233 | 0.85 | POLB (0.43) | POLBLMNAKDM4EKMT2APDE11A | |
| SCHEMBL8600136 | 0.81 | LMNA (0.44) | POLBLMNAKDM4EPDE11AHTT | |
| SCHEMBL8600133 | 0.81 | LMNA (0.44) | POLBLMNAKDM4EPDE11AHTT | |
| SCHEMBL8299687 | 0.81 | LMNA (0.44) | POLBLMNAKDM4EKMT2APDE11A | |
| SCHEMBL8299688 | 0.81 | LMNA (0.44) | POLBLMNAKDM4EKMT2APDE11A | |
| SCHEMBL8301788 | 0.81 | POLB (0.46) | POLBLMNAKDM4EKMT2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716993-A | PHOSPHODIESTERASE ENZYME INHIBITOR FOR TREATING CARDIOVASCULAR DISORDER, ANGINA PECTORIS, HYPERTENSION, ASTHMA | EISAI CO., LTD. (JP) | 1998-02-10 | — | — | US | disclosed |