SCHEMBL860227

SCHEMBL860227

C1=C2CCNCCN2CCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 1/20 0.41
USP2 O75604 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CASP1 P29466 1/20 0.39
CASP4 P49662 1/20 0.39
CASP5 P51878 1/20 0.39
HRH4 Q9H3N8 1/20 0.38
ADRB1 P08588 5/20 0.36
HTR3E A5X5Y0 2/20 0.36
HTR3B O95264 2/20 0.36
HTR3A P46098 2/20 0.36
HTR3D Q70Z44 2/20 0.36
HTR3C Q8WXA8 2/20 0.36
SIGMAR1 Q99720 2/20 0.36
HTR2C P28335 3/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15526123 0.87 USP2 (0.40) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL7302082 0.86 HTR2C (0.39) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL30169372 0.84 CHRNB2 (0.36) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL30169373 0.84 CHRNB2 (0.36) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL10437043 0.82 SMN1; SMN2 (0.43) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL3810433 0.82 HTR2C (0.40) HRH1USP2SMN1; SMN2TDP1CASP1
SCHEMBL16556908 0.79 KDM4E (0.39) HRH1ADRB1HTR3EHTR3BHTR3A
SCHEMBL389739 0.78
SCHEMBL368150 0.76 MAPT (0.37) USP2ALDH1A1
SCHEMBL15310285 0.76 TDP1 (0.36) HRH1USP2SMN1; SMN2TDP1CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5747557-A MIXING UNDER SHEAR FORCE; UNIFORM DISPERSION KABUSHIKI KAISHA TOSHIBA (JP) 1998-05-05 US claimed
JP-7112951-A None JP disclosed
US-20260124319-A1 NANOPARTICLES COMPRISING P52K PROTEIN AND ONE OR MORE NUCLEIC ACIDS AND, OR PROTEINS OF INTEREST AND METHODS OF USE THEREOF FOR DELIVERY TO CELLS THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2026-05-07 US disclosed
EP-4731769-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCERS BY TRIGGERING ANTI-VIRAL RESPONSE Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2026-04-29 EP disclosed
WO-2026041519-A1 METHOD FOR PRODUCING A RECYCLABLE MONO-MATERIAL MULTI-LAYER SYSTEM COVESTRO DEUTSCHLAND AG (DE) 2026-02-26 WO disclosed
EP-4680251-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER Thomas Jefferson University (US) 2026-01-21 EP disclosed
US-12440560-B2 Substituted pyrimidines as vaccine adjuvants Sumitomo Pharma Co., Ltd. (JP) 2025-10-14 US disclosed
EP-3603619-B1 VACCINE ADJUVANT FORMULATION SUMITOMO PHARMA CO LTD (JP) 2025-08-13 EP disclosed
EP-3252068-B1 METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING OLIGONUCLEOTIDE BASED DRUGS ADMINISTERED IN VIVO OR IN VITRO SMITH LARRY J (US) 2025-07-02 EP disclosed
US-12319914-B2 Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro SMITH LARRY J (US) 2025-06-03 US disclosed
EP-0718345-B1 Modification of resins with isocyanatosiloxanes SHINETSU CHEMICAL CO (JP) 2000-03-29 EP disclosed
WO-1999041267-A1 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES GLAXO GROUP LIMITED (GB) 1999-08-19 WO disclosed
US-5703159-A REACTING RESIN HAVING ISOCYANATE-REACTIVE GROUP ON SIDE CHAIN WITH SINGLE END ISOCYANATOSILOXANE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-12-30 US disclosed
EP-0718345-A1 Modification of resins with isocyanatosiloxanes Shin-Etsu Chemical Co., Ltd. (JP) 1996-06-26 EP disclosed
JP-H07112951-A SYNTHESIS OF OPTICALLY ACTIVE CYCLOHEXENONE DERIVATIVE AMANO PHARMACEUT CO LTD 1995-05-02 JP disclosed
US-5260285-A Substituted imidazopyridazines as angiotensin II antagonists MERCK & CO., INC. (US) 1993-11-09 US disclosed
US-5250521-A Administering in treatment of eleuated blood pressure, conjestive heart failure and ocular hypertension MERCK & CO., INC. (US) 1993-10-05 US disclosed
EP-0530690-A2 1-Azabicycle(4,3,1)decane BASF Aktiengesellschaft (DE) 1993-03-10 EP disclosed
EP-0490587-A1 Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin II antagonists MERCK & CO. INC. (US) 1992-06-17 EP disclosed
EP-0373531-A1 Novel pyridobenzoxazine derivative WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1990-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124319-A1 NANOPARTICLES COMPRISING P52K PROTEIN AND ONE OR MORE NUCLEIC ACIDS AND, OR PROTEINS OF INTEREST AND METHODS OF USE THEREOF FOR DELIVERY TO CELLS EIF2AK2, EIF2AK1, CIP2A HRH1 3481/4885USP2 167/4885SMN1; SMN2 1173/4885
US-12440560-B2 Substituted pyrimidines as vaccine adjuvants TYMS, UMPS, P2RY1 HRH1 445/4885USP2 3414/4885SMN1; SMN2 2581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.