SCHEMBL860266

SCHEMBL860266

O=C(ON1C(=O)c2ccc(C(c3ccc4c(c3)C(=O)N(OC(=O)c3ccccc3)C4=O)(C(F)(F)F)C(F)(F)F)cc2C1=O)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP1A2 P05177 1/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
POLB P06746 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA9 Q16790 1/20 0.37
F2 P00734 2/20 0.34
MASP2 O00187 1/20 0.34
MAPT P10636 3/20 0.34
GAA P10253 1/20 0.34
CYP2C19 P33261 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HPGD P15428 1/20 0.34
LMNA P02545 2/20 0.34
NR1H2 P55055 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL859908 0.86 CES2 (0.37) KMT2AMEN1CA12CA1CA9
SCHEMBL859763 0.82 KDM4E (0.37) ALDH1A1POLBCA12CA1CA9
SCHEMBL859762 0.81 CA9 (0.37) ALDH1A1POLBCA12CA1CA9
SCHEMBL860269 0.81 MAPT (0.40) ALDH1A1CYP2C9CYP1A2KMT2APOLB
SCHEMBL491136 0.79 ALDH1A1 (0.57) ALDH1A1CYP2C9CYP1A2KMT2APOLB
SCHEMBL859698 0.78 APEX1 (0.52) ALDH1A1CYP2C9CYP1A2KMT2AMEN1
SCHEMBL29082812 0.77 ALDH1A1 (0.56) ALDH1A1CYP2C9CYP1A2KMT2APOLB
SCHEMBL860087 0.77 TDP1 (0.52) ALDH1A1CYP2C9CYP1A2KMT2AMEN1
SCHEMBL860085 0.76 TNF (0.38) ALDH1A1POLBSMN1; SMN2CA12CA1
SCHEMBL860083 0.75 TNF (0.39) ALDH1A1CYP2C9CYP1A2KMT2ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed