Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 20/20 | 0.53 |
| ▸ | RARG | P13631 | 20/20 | 0.53 |
| ▸ | RARA | P10276 | 18/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605739 | 0.91 | RARB (0.53) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8605671 | 0.87 | RARB (0.43) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8633708 | 0.85 | RARB (0.38) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8605703 | 0.79 | RARB (0.55) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8633713 | 0.70 | RARB (0.33) | RARBRARGRARA | |
| SCHEMBL8866799 | 0.70 | RARB (0.55) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9484699 | 0.69 | RARB (0.69) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8776480 | 0.69 | RARB (0.83) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL29353973 | 0.69 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL3302926 | 0.69 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825986-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | Allergan (US) | 1998-03-04 | — | — | EP | claimed |
| US-5616712-A | SKIN DISORDERS; ANTICARCINOGENIC AND -INFLAMMATORY AGENTS; AUTOIMMUNE DISEASES; | ALLERGAN (US) | 1997-04-01 | — | — | US | claimed |
| WO-1996036609-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN (US) | 1996-11-21 | — | — | WO | claimed |
| US-5616712-A | SKIN DISORDERS; ANTICARCINOGENIC AND -INFLAMMATORY AGENTS; AUTOIMMUNE DISEASES; | ALLERGAN (US) | 1997-04-01 | — | — | US | disclosed |