Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315580 | 0.89 | PTGS2 (0.45) | PTGS2PTGS1RXRASCN9AEPHX2 | |
| SCHEMBL8604021 | 0.87 | PTGS1 (0.41) | PTGS2PTGS1RXRAEPHX2NR4A2 | |
| SCHEMBL8604398 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1RXRAEPHX2RXRB | |
| SCHEMBL6308151 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1RXRAEPHX2NR4A2 | |
| SCHEMBL8604310 | 0.85 | RXRA (0.43) | RXRANR4A2RXRBRXRGF10 | |
| SCHEMBL6309069 | 0.83 | NR4A2 (0.49) | PTGS2PTGS1RXRAEPHX2NR4A2 | |
| SCHEMBL7520783 | 0.83 | AURKA (0.45) | PTGS2PTGS1AURKAROCK2RPS6KA5 | |
| SCHEMBL8561125 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1RXRASCN9AEPHX2 | |
| SCHEMBL6307441 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1RXRAEPHX2NR4A2 | |
| SCHEMBL6309656 | 0.82 | NR4A2 (0.51) | PTGS2PTGS1RXRAEPHX2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |