Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.43 |
| ▸ | RXRB | P28702 | 7/20 | 0.43 |
| ▸ | RXRG | P48443 | 6/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 8/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604310 | 0.92 | RXRA (0.43) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL6308847 | 0.87 | RXRA (0.46) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL8605984 | 0.84 | RXRA (0.47) | RXRARXRBRXRGNR4A2CA2 | |
| SCHEMBL8604308 | 0.84 | RXRA (0.47) | RXRARXRBRXRGNR4A2CA2 | |
| SCHEMBL8604021 | 0.83 | PTGS1 (0.41) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL6309740 | 0.83 | RXRA (0.49) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8606386 | 0.82 | KDM4E (0.46) | RXRARXRBRXRGNR4A2F10 | |
| SCHEMBL8607286 | 0.82 | PTGS1 (0.40) | RXRARXRBRXRGNR4A2CA9 | |
| SCHEMBL8604374 | 0.82 | NR4A2 (0.47) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8606987 | 0.80 | CA2 (0.41) | F10CA2CA9KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |