Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | USP19 | O94966 | 1/20 | 0.35 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604310 | 0.90 | RXRA (0.43) | CA9NR4A2NAMPTRXRARXRB | |
| SCHEMBL6860700 | 0.90 | PTGS1 (0.41) | PTGS1PTGS2CA9NR4A2TRPV1 | |
| SCHEMBL8604021 | 0.87 | PTGS1 (0.41) | PTGS1PTGS2CA9NR4A2RXRA | |
| SCHEMBL6308687 | 0.87 | NR4A2 (0.44) | PTGS1PTGS2CA9NR4A2TRPV1 | |
| SCHEMBL8607283 | 0.84 | PTGS2 (0.57) | PTGS1PTGS2CA9NR4A2 | |
| SCHEMBL8556142 | 0.83 | PTGS2 (0.46) | PTGS1PTGS2CA9NR4A2TRPV1 | |
| SCHEMBL8605986 | 0.82 | RXRA (0.43) | CA9NR4A2NAMPTRXRARXRB | |
| SCHEMBL8606455 | 0.82 | NR4A2 (0.47) | PTGS1PTGS2NR4A2RXRARXRB | |
| SCHEMBL8558402 | 0.81 | PTGS2 (0.44) | PTGS1PTGS2NR4A2TRPV1RXRA | |
| SCHEMBL8604402 | 0.81 | PTGS2 (0.43) | PTGS1PTGS2NR4A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |