Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30589181 | 0.80 | CYP19A1 (0.50) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL29138449 | 0.80 | CYP19A1 (0.50) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL24608491 | 0.80 | CYP19A1 (0.50) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL30048933 | 0.80 | CYP19A1 (0.50) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL29583584 | 0.76 | KIF11 (0.61) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL74389 | 0.76 | KIF11 (0.61) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL3847927 | 0.74 | KIF11 (0.41) | CYP19A1LMNAKIF11CYP17A1 | |
| SCHEMBL27996644 | 0.74 | CYP19A1 (0.57) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL56734 | 0.73 | MAPK1 (0.44) | CYP1A2CYP3A4 | |
| SCHEMBL22714972 | 0.73 | CYP19A1 (0.43) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807852-A | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases | SCHERING CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| US-5807853-A | Tricyclic amide and urea compounds, useful inhibition of g-protein function and for treatment of proliferative diseases | SCHERING CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| US-5719148-A | FARNESYL-PROTEIN TRANSFERASE INHIBITORS | SCHERING CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| US-5714609-A | FORMING CHEMICAL INTERMEDIATE BY NITRATING SUBSTITUTED BENZO/5,6/CYCLOHEPTA/1,2-B/PYRIDINE WITH TETRABUTYLAMMONIUM NITRATE AND TRIFLUOROACETIC ANHYDRIDE IN SOLVENT AT REDUCED TEMPERATURE | SCHERING CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| US-5700806-A | FARNESYL PROTEIN TRANSFERASE ENZYME INHIBITOR, ANTITUMOR AGENTS | SCHERING CORPORATION (US) | 1997-12-23 | — | — | US | disclosed |
| US-5696121-A | 4-(3-BROMO 8-CHLORO-6,11-DIHYDRO-5H-BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE-11-YL)-N-(3 -PYRIDINYL)-1-PIPERAZINECARBOXIDE; ANTITUMOR AGENT; FARNESYL PROTEIN TRANSFERASE INHIBITOR | SCHERING CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |