Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 10/20 | 0.39 |
| ▸ | NPC1 | O15118 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608866 | 0.82 | SUV39H2 (0.38) | ALDH1A1KDM4EKMT2AMEN1HSP90AA1 | |
| SCHEMBL8607791 | 0.80 | APP (0.36) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8607360 | 0.79 | ALDH1A3 (0.45) | ALDH1A1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL8610050 | 0.78 | TBXAS1 (0.42) | SMN1; SMN2HSD17B10 | |
| SCHEMBL8606962 | 0.78 | KDM6B (0.35) | ALDH1A1KDM4EKMT2AMEN1HSP90AA1 | |
| SCHEMBL8608922 | 0.77 | ALDH1A1 (0.33) | ALDH1A1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL8607307 | 0.76 | APP (0.34) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8606803 | 0.74 | CPB2 (0.36) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4726717 | 0.74 | ALDH1A1 (0.68) | ALDH1A1KDM4EKMT2AMEN1HSP90AA1 | |
| SCHEMBL8607617 | 0.74 | KDM4E (0.36) | KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| US-5763597-A | Orally active adenosine kinase inhibitors | METABASIS THERAPEUTICS, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5721356-A | SUBSTITUTED 5-ARYLPYRROLO(2,3-D)PYRIMIDINE OR 3-ARYLPYRAZOLO(3,4-D)PYRIMIDINE; CARDIOVASCULAR DISORDERS, BRAIN DISORDERS, ANTIINFLAMMATORY AGENTS | GENSIA, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |