Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 5/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609061 | 0.83 | PTPRA (0.38) | PTPRAKDM6BMME | |
| SCHEMBL8608522 | 0.82 | PPARG (0.38) | TGFBR1TBXAS1 | |
| SCHEMBL8607229 | 0.80 | LMNA (0.35) | TGFBR1 | |
| SCHEMBL8605173 | 0.80 | P4HTM (0.36) | TGFBR1TBXAS1P4HTM | |
| SCHEMBL9753609 | 0.78 | — | — | |
| SCHEMBL8606789 | 0.77 | TBXAS1 (0.45) | TGFBR1TBXAS1P4HTM | |
| Methyl Alcohol SCHEMBL9753918 | 0.77 | TBXAS1 (0.36) | TGFBR1TBXAS1P4HTM | |
| SCHEMBL8607304 | 0.76 | PGK1 (0.37) | TGFBR1SMN1; SMN2TBXAS1 | |
| SCHEMBL8605178 | 0.76 | PTPRA (0.35) | PTPRAKDM6BMME | |
| SCHEMBL9753517 | 0.75 | HDAC4 (0.40) | TGFBR1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| US-5716964-A | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | G.D. SEARLE & CO. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |