Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860569 | 0.94 | L3MBTL1 (0.36) | L3MBTL1MPOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20024879 | 0.90 | ALDH1A1 (0.39) | L3MBTL1MPOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30474571 | 0.90 | ALDH1A1 (0.39) | L3MBTL1MPOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29702271 | 0.89 | MPO (0.39) | MPOKDM4ENPC1RAB9AFGFR4 | |
| SCHEMBL13355467 | 0.89 | MPO (0.39) | MPOKDM4ENPC1RAB9AFGFR4 | |
| SCHEMBL29416368 | 0.88 | HPGD (0.37) | L3MBTL1MPOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17921404 | 0.88 | HPGD (0.37) | L3MBTL1MPOKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4523127 | 0.87 | MPO (0.40) | MPONPC1RAB9AFGFR4ESR2 | |
| SCHEMBL30474562 | 0.87 | MPO (0.40) | MPONPC1RAB9AFGFR4ESR2 | |
| SCHEMBL17642774 | 0.87 | MPO (0.41) | MPONPC1RAB9AFGFR4ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665458-A1 | INHIBITING ALPHA V BETA8 INTEGRIN | Morphic Therapeutic, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173572-A1 | INHIBITING α vβ8 INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2024-08-22 | — | — | WO | disclosed |
| US-9701660-B2 | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system | AC IMMUNE S.A. (CH) | 2017-07-11 | — | — | US | disclosed |
| US-9701660-B2 | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system | AC IMMUNE S.A. (CH) | 2017-07-11 | — | — | US | disclosed |
| US-20150023950-A1 | 2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System | AC IMMUNE S.A. (CH) | 2015-01-22 | — | — | US | disclosed |
| US-20150023950-A1 | 2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System | AC IMMUNE S.A. (CH) | 2015-01-22 | — | — | US | disclosed |
| US-8916590-B2 | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system | AC IMMUNE SA (CH) | 2014-12-23 | — | — | US | disclosed |
| US-8916590-B2 | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system | AC IMMUNE SA (CH) | 2014-12-23 | — | — | US | disclosed |
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-B1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20050250771-A1 | Substituted indoles and their use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-11-10 | — | — | US | disclosed |
| US-20050228011-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-10-13 | — | — | US | disclosed |
| US-20050209225-A1 | Substituted indoles and their use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-09-22 | — | — | US | disclosed |
| US-20050165036-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-07-28 | — | — | US | disclosed |
| US-6872730-B2 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-6855722-B2 | Substituted indoles and their use as integrin antagonists | DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20030018064-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-01-23 | — | — | US | disclosed |
| US-20020169200-A1 | Substituted indoles and their use as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-11-14 | — | — | US | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165036-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | ITGB5, ITGAV, ITGB1 | L3MBTL1 3212/4885MPO 3892/4885KDM4E 1347/4885 |
| US-20030018064-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | VCAM1, ITGB1, ITGB7 | L3MBTL1 3165/4885MPO 4141/4885KDM4E 1757/4885 |
| US-20050209225-A1 | Substituted indoles and their use as integrin antagonists | ITGAV, ITGA5, ITGB5 | L3MBTL1 3467/4885MPO 3730/4885KDM4E 1764/4885 |
| US-20150023950-A1 | 2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System | APP, CLN6, DPYSL2 | L3MBTL1 4118/4885MPO 2726/4885KDM4E 3964/4885 |
| US-20050228011-A1 | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists | ITGB5, ITGAV, ITGB1 | L3MBTL1 3212/4885MPO 3892/4885KDM4E 1347/4885 |
| US-20020169200-A1 | Substituted indoles and their use as integrin antagonists | ITGAV, ITGAL, ITGA5 | L3MBTL1 3165/4885MPO 4041/4885KDM4E 1966/4885 |
| US-20050250771-A1 | Substituted indoles and their use as integrin antagonists | ITGAV, ITGA5, ITGB5 | L3MBTL1 3429/4885MPO 3811/4885KDM4E 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.