SCHEMBL861263

SCHEMBL861263

CC(C)(C)Cc1nc2nc(N)c3ccccc3c2n1CC(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 16/20 0.45
TLR8 Q9NR97 6/20 0.45
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
GAA P10253 1/20 0.36
PKM P14618 1/20 0.36
NUDT1 P36639 1/20 0.36
GRM2 Q14416 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL861486 0.83 TLR7 (0.41) TLR7TLR8MEN1KMT2AGAA
SCHEMBL15978916 0.66 MEN1 (0.68) MEN1KMT2AGAAPKM
SCHEMBL20080779 0.66 TLR7 (0.77) TLR7TLR8NUDT1
SCHEMBL861265 0.65 MEN1 (0.32) TLR7TLR8MEN1KMT2AGAA
SCHEMBL18292495 0.65 TLR7 (0.71) TLR7TLR8NUDT1
SCHEMBL19345034 0.64 TLR7 (0.76) TLR7TLR8
SCHEMBL21741933 0.63 TLR7 (0.83) TLR7TLR8
SCHEMBL20199817 0.62 TLR7 (1.00) TLR7TLR8NUDT1
SCHEMBL861239 0.61 DCPS (0.36) TLR7TLR8GAA
SCHEMBL861436 0.60 APP (0.43) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
WO-2008156879-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION (US) 2008-12-24 WO disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS IK, CRY1, MAP1LC3C TLR7 4288/4885TLR8 4706/4885MEN1 1124/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.