Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | ACR | P10323 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609393 | 0.94 | HDAC3 (0.38) | PRSS1ACRHDAC3HDAC1HDAC2 | |
| SCHEMBL9018706 | 0.93 | PTGS1 (0.38) | HDAC3HDAC1HDAC2NOS3NOS1 | |
| SCHEMBL9018679 | 0.89 | NOS3 (0.40) | NOS3NOS1NOS2SLC6A2SLC6A4 | |
| SCHEMBL8612846 | 0.87 | MRGPRX4 (0.38) | HDAC3HDAC1HDAC2NOS3NOS1 | |
| SCHEMBL8614188 | 0.83 | MRGPRX4 (0.40) | NOS3NOS1NOS2SLC6A2SLC6A4 | |
| SCHEMBL9018659 | 0.81 | PLK1 (0.40) | — | |
| SCHEMBL8612829 | 0.80 | CFTR (0.46) | PPARGNR1H2NR1H3 | |
| SCHEMBL9018694 | 0.78 | SLC9A1 (0.44) | — | |
| SCHEMBL9018732 | 0.77 | FFAR4 (0.40) | — | |
| SCHEMBL9018672 | 0.76 | PIM1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743301-A2 | Benzoylguanidines containing fluorine | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |