Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611582 | 0.91 | CFTR (0.51) | SLC9A1PLAUCES2KDM4ECFTR | |
| SCHEMBL9018692 | 0.90 | SLC9A1 (0.41) | SLC9A1PLAUCES2SLC9A5KDM4E | |
| SCHEMBL9018659 | 0.88 | PLK1 (0.40) | SLC9A1PLAUCES2SLC9A5 | |
| SCHEMBL24720949 | 0.84 | JAK2 (0.50) | CES2JAK2JAK1TYK2KDM4E | |
| SCHEMBL8612587 | 0.83 | CFTR (0.48) | SLC9A1CES2CFTR | |
| SCHEMBL9018705 | 0.82 | SLC9A1 (0.48) | SLC9A1PLAUCES2 | |
| SCHEMBL8612829 | 0.81 | CFTR (0.46) | SLC9A1CFTR | |
| SCHEMBL9018662 | 0.80 | CES2 (0.62) | SLC9A1PLAUCES2SLC9A5KDM4E | |
| SCHEMBL9018707 | 0.80 | SLC9A1 (0.46) | SLC9A1PLAUCES2KDM4EALDH1A1 | |
| SCHEMBL9018685 | 0.79 | CES2 (0.49) | SLC9A1PLAUCES2SLC9A5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743301-A2 | Benzoylguanidines containing fluorine | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |