SCHEMBL8612914

SCHEMBL8612914

Fc1cc(OCc2ccccc2)ccc1-c1ccc(-c2ccc(Br)c(F)c2F)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.44
S1PR1 P21453 1/20 0.44
S1PR3 Q99500 1/20 0.44
GSTP1 P09211 2/20 0.44
MAOB P27338 4/20 0.43
TOP1 P11387 1/20 0.42
MAOA P21397 3/20 0.41
FFAR1 O14842 3/20 0.41
PPARD Q03181 1/20 0.41
CTSV O60911 1/20 0.40
CTSL P07711 1/20 0.40
MCL1 Q07820 1/20 0.40
PDK2 Q15119 1/20 0.39
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
NAAA Q02083 1/20 0.39
RHEB Q15382 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616628 0.96 GSTP1 (0.45) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8612316 0.94 ALOX5 (0.50) ALOX5GSTP1MAOBTOP1MAOA
SCHEMBL8612910 0.94 ALOX5 (0.50) ALOX5GSTP1MAOBTOP1MAOA
SCHEMBL8616555 0.93 ALOX5 (0.44) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8612156 0.93 GSTP1 (0.49) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8612487 0.91 GSTP1 (0.48) ALOX5GSTP1MAOBTOP1MAOA
SCHEMBL8616606 0.91 GSTP1 (0.51) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8613875 0.90 GSTP1 (0.48) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8618479 0.90 GSTP1 (0.48) ALOX5S1PR1S1PR3GSTP1MAOB
SCHEMBL8616533 0.87 GSTP1 (0.48) ALOX5S1PR1S1PR3GSTP1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665836-B1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AG (DE) 1998-04-29 EP disclosed
EP-0665836-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-09 EP disclosed
WO-1994010152-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-11 WO disclosed