SCHEMBL8612957

SCHEMBL8612957

CCOC(=O)Cn1c(=O)c(=O)[nH]c2c3ccccc3ccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
KDM4E B2RXH2 6/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
RAB9A P51151 1/20 0.49
HSD17B10 Q99714 3/20 0.46
HPGD P15428 2/20 0.46
TSHR P16473 1/20 0.46
SAE1 Q9UBE0 1/20 0.46
UBA2 Q9UBT2 1/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
HTT P42858 1/20 0.45
TNF P01375 1/20 0.44
USP2 O75604 1/20 0.43
CTNNB1 P35222 1/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8609389 0.85 ALDH1A1 (0.41) ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL8610724 0.83 FDPS (0.48) ALDH1A1KDM4EHSD17B10HPGDMEN1
SCHEMBL7486654 0.81 CYP1A2 (0.49) ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL8613667 0.80 GRIA1 (0.39) ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL8622802 0.77 KDM4E (0.38) ALDH1A1KDM4ECYP1A2HSD17B10HPGD
SCHEMBL9395672 0.77 RORA (0.52) ALDH1A1KDM4EHSD17B10HPGDTDP1
SCHEMBL9396447 0.75 SMN1; SMN2 (0.53) ALDH1A1KDM4EHSD17B10HPGDTDP1
SCHEMBL9395611 0.75 SMN1; SMN2 (0.53) ALDH1A1KDM4EHSD17B10HPGDTDP1
SCHEMBL7352636 0.74 GRIN2D (0.47) ALDH1A1KDM4EHSD17B10HPGDMEN1
SCHEMBL9395727 0.74 KDM4E (0.48) ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5852017-A 2,3(1H,4H)-quinoxalinediones BASF AKTIENGESELLSCHAFT (DE) 1998-12-22 US disclosed
US-5714489-A 2,3(1H,4H)quinoxalinedione BASF AKTIENGESELLSCHAFT (DE) 1998-02-03 US disclosed