Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619418 | 0.86 | CCR6 (0.68) | PDE10AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8619721 | 0.85 | MEN1 (0.45) | PDE10AKDM4EMMP2MEN1GFER | |
| SCHEMBL8614378 | 0.84 | MEN1 (0.44) | PDE10AKDM4ELMNAMMP2MEN1 | |
| SCHEMBL8618698 | 0.82 | PDE10A (0.62) | PDE10AKDM4ELMNASMN1; SMN2PPARA | |
| SCHEMBL11810641 | 0.81 | PDE10A (0.70) | PDE10AKDM4ELMNASMN1; SMN2PPARA | |
| SCHEMBL6429299 | 0.78 | KDM4E (0.80) | PDE10AKDM4ELMNASMN1; SMN2PPARA | |
| SCHEMBL8619728 | 0.77 | KEAP1 (0.43) | KDM4ELMNAHTTMMP2ALDH1A1 | |
| SCHEMBL13958056 | 0.76 | CCR6 (0.68) | PDE10AKDM4ELMNASMN1; SMN2PPARA | |
| SCHEMBL22471898 | 0.75 | AURKA (0.78) | PDE10AKDM4ELMNASMN1; SMN2PPARA | |
| SCHEMBL8619739 | 0.75 | PPARA (0.69) | PDE10AKDM4ELMNASMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |