Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.64 |
| ▸ | F2 | P00734 | 3/20 | 0.64 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.64 |
| ▸ | PLG | P00747 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.53 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860152 | 0.78 | PRSS1 (1.00) | PRSS1PRSS2PRSS3F2ST14 | |
| SCHEMBL6965406 | 0.73 | AVPR2 (0.92) | TSHRALDH1A1LMNAHPGDAVPR2 | |
| SCHEMBL3456212 | 0.73 | TSHR (0.77) | TSHRALDH1A1LMNAHPGDPDE4A | |
| SCHEMBL7348349 | 0.73 | AVPR2 (0.76) | TSHRALDH1A1LMNAHPGDAVPR2 | |
| SCHEMBL29463754 | 0.73 | ALDH1A1 (0.81) | TSHRALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL6198498 | 0.73 | ALDH1A1 (0.81) | TSHRALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL5243307 | 0.72 | AVPR2 (0.80) | TSHRALDH1A1LMNAAVPR2AVPR1A | |
| Thiourea SCHEMBL15400235 | 0.72 | ALDH1A1 (0.70) | TSHRALDH1A1HPGDPOLBMAPT | |
| SCHEMBL29941834 | 0.72 | PDE4A (1.00) | TSHRALDH1A1LMNAHPGDPDE4A | |
| SCHEMBL4493929 | 0.72 | ALDH1A1 (0.71) | TSHRALDH1A1LMNAHPGDAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | TSHR 3955/4885PRSS1 3/4885PRSS2 23/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | TSHR 3955/4885PRSS1 3/4885PRSS2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.