SCHEMBL8614719

SCHEMBL8614719

Fc1cc(OCc2ccccc2)ccc1-c1cnc(Cl)cn1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 4/20 0.49
ALOX5AP P20292 2/20 0.49
TOP1 P11387 1/20 0.44
ALOX5 P09917 1/20 0.43
MAOA P21397 5/20 0.43
MAOB P27338 5/20 0.43
MAPT P10636 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
KDM4E B2RXH2 1/20 0.42
HSP90AA1 P07900 1/20 0.42
MAPK1 P28482 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PDK2 Q15119 1/20 0.41
HDAC1 Q13547 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
CYP3A4 P08684 1/20 0.40
GRM5 P41594 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8613864 0.85 MEN1 (0.46) FEN1ALOX5APTOP1ALOX5MAOA
SCHEMBL8619233 0.85 MAOB (0.44) FEN1ALOX5APTOP1ALOX5MAOA
SCHEMBL8615466 0.82 S1PR1 (0.48) FEN1TOP1ALOX5MAOAMAOB
SCHEMBL8612974 0.80 MAOB (0.48) TOP1ALOX5MAOAMAOBMAPT
SCHEMBL21835699 0.79 FFAR1 (0.41) FEN1ALOX5APMAOB
SCHEMBL21835658 0.79 FEN1 (0.44) FEN1ALOX5APMAPTMAPK1TDP1
SCHEMBL8612536 0.79 MAPT (0.46) FEN1TOP1ALOX5MAOAMAOB
SCHEMBL8615058 0.79 TOP1 (0.46) TOP1ALOX5MAOAMAOBMAPT
SCHEMBL8614763 0.78 RAB9A (0.54) MAOAMAOBMAPTHDAC6
SCHEMBL8616563 0.78 FEN1 (0.56) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665836-B1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AG (DE) 1998-04-29 EP disclosed
EP-0665836-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-09 EP disclosed
WO-1994010152-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-11 WO disclosed