Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838141 | 0.98 | MAPT (0.79) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL9838136 | 0.98 | MAPT (0.79) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL23377537 | 0.98 | MAPT (0.79) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL1304425 | 0.94 | MAPT (0.85) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL8049689 | 0.94 | MAPT (0.85) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL8049692 | 0.94 | MAPT (0.85) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL1304422 | 0.94 | MAPT (0.85) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL14391815 | 0.93 | ESR1 (0.73) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL9839256 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTKDM4EHPGDESR1 | |
| SCHEMBL13070554 | 0.88 | KDM4E (0.74) | ALDH1A1MAPTKDM4EHPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720597-B1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMA INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693674-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5691384-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5684004-A | ANTINEOPLASTIC AGENTS, ANTIATHEROSCLEROTIC AGENTS, HYPOCHOLESTEROLEMIC AGENTS | MERRELL PHARMACEUTICALS, INC. (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5663207-A | ADMINISTERING TO INHIBIT DEVELOPMENT OF BREAST TUMOR | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-09-02 | — | — | US | disclosed |
| US-5658914-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| US-5658951-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| US-5658927-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0720597-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5525633-A | ANTITUMOR AGENTS, ANTICHOLESTEROL AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1995008528-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |
| US-5397802-A | Gem-dichlorocyclopropanes as antitumor agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-14 | — | — | US | disclosed |
| US-4879315-A | Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents | THE BOARD OF REGENTS FOR THE UNIVERSITY OF OKLAHOMA (US) | 1989-11-07 | — | — | US | disclosed |