Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 14/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803941 | 0.86 | USP30 (0.41) | SLC5A1 | |
| SCHEMBL1803943 | 0.86 | USP30 (0.41) | SLC5A1 | |
| SCHEMBL860923 | 0.86 | BACE1 (0.41) | ACMSDBACE1SLC5A1 | |
| SCHEMBL860924 | 0.86 | BACE1 (0.41) | ACMSDBACE1SLC5A1 | |
| SCHEMBL2599154 | 0.81 | RORC (0.37) | PARP1HCRTR1HCRTR2 | |
| SCHEMBL2598841 | 0.81 | ACMSD (0.39) | ACMSDBACE1SLC5A1PARP1HCRTR1 | |
| SCHEMBL861829 | 0.81 | HDAC2 (0.40) | PARP1 | |
| SCHEMBL1805585 | 0.81 | ACMSD (0.39) | ACMSDBACE1SLC5A1PARP1HCRTR1 | |
| SCHEMBL1805583 | 0.81 | ACMSD (0.39) | ACMSDBACE1SLC5A1PARP1HCRTR1 | |
| SCHEMBL2598843 | 0.81 | ACMSD (0.39) | ACMSDBACE1SLC5A1PARP1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |