Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613101 | 0.90 | ACE (0.38) | P2RX7TSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8615391 | 0.80 | ADRA1A (0.43) | P2RX7USP2ALDH1A1KMT2A | |
| SCHEMBL8614999 | 0.79 | P2RX7 (0.34) | P2RX7TSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL27537862 | 0.74 | MEN1 (0.49) | P2RX7USP2ALDH1A1KMT2A | |
| SCHEMBL20077497 | 0.73 | RORC (0.35) | P2RX7TSHRUSP2ALDH1A1KMT2A | |
| SCHEMBL9383119 | 0.71 | ACE (0.36) | P2RX7TSHRALDH1A1KMT2A | |
| SCHEMBL9544626 | 0.71 | ACE (0.36) | P2RX7TSHRALDH1A1KMT2A | |
| SCHEMBL10561504 | 0.69 | P2RX7 (0.35) | P2RX7KMT2A | |
| SCHEMBL8613094 | 0.69 | ACE (0.40) | P2RX7TSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL30684620 | 0.68 | P2RX7 (0.37) | P2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |