Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29576625 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HSD17B10MAP3K11KIF11HTR3A | |
| SCHEMBL28826859 | 0.84 | PIK3CD (0.53) | ALDH1A1HSD17B10MAP3K11KIF11ERCC1 | |
| SCHEMBL29576228 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HTR3AERCC1DNASE1 | |
| SCHEMBL7291426 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HTR3AERCC1DNASE1 | |
| SCHEMBL5097444 | 0.80 | HTR3A (0.57) | ALDH1A1HSD17B10HTR3AGAAKDM4E | |
| SCHEMBL9569216 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HSD17B10MAP3K11ERCC1DNASE1 | |
| SCHEMBL9569202 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAP3K11ERCC1DNASE1 | |
| SCHEMBL20443487 | 0.77 | HTR3A (0.50) | ALDH1A1HSD17B10HTR3AGAAKDM4E | |
| SCHEMBL949366 | 0.75 | HTR3A (0.56) | HTR3AGAAKDM4EMAPTMAPK1 | |
| SCHEMBL18436001 | 0.74 | ADRA2C (0.47) | ALDH1A1HSD17B10HTR3AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831845-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1998-12-02 | — | — | EP | claimed |
| EP-0831845-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040156-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | claimed |