SCHEMBL8615822

SCHEMBL8615822

CON=C(C=NOC(C)c1ccccc1C(=NOC)C(N)=O)c1ccc(F)cc1F

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.33
RECQL P46063 1/20 0.31
NPC1 O15118 1/20 0.31
POLB P06746 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
PARP14 Q460N5 1/20 0.31
PARP10 Q53GL7 1/20 0.31
CES2 O00748 2/20 0.31
CES1 P23141 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7784487 0.91 RECQL (0.32) MAPK14RECQLCES2CES1
SCHEMBL6704054 0.91 HIF1A (0.36) MAPK14RECQLCES2CES1
SCHEMBL7498115 0.84 HIF1A (0.36) NPC1POLBRAB9AKMT2A
SCHEMBL7542494 0.83 NPC1 (0.30) NPC1POLBRAB9AKMT2A
SCHEMBL7504420 0.82 HIF1A (0.38) NPC1RAB9AKMT2A
SCHEMBL7492778 0.82 HIF1A (0.36)
SCHEMBL7500247 0.81
SCHEMBL7498643 0.81 ALDH1A1 (0.34) NPC1RAB9AKMT2A
SCHEMBL7502694 0.80 HIF1A (0.42) PARP14PARP10
SCHEMBL7504773 0.79 LMNA (0.36) KMT2APARP14PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0837856-A1 PESTICIDAL TRIS-OXIMINO HETEROCYCLIC COMPOUNDS Novartis AG (CH) 1998-04-29 EP disclosed
WO-1997000866-A1 PESTICIDAL TRIS-OXIMINO HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 1997-01-09 WO disclosed