Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536263 | 0.89 | ROCK2 (0.47) | ROCK2CASRPTGS1PTGS2SLC7A5 | |
| SCHEMBL29214272 | 0.84 | PTGS1 (0.56) | CASRLOXL2RAB9APTGS1PTGS2 | |
| SCHEMBL27486840 | 0.81 | SLC7A5 (0.44) | CASRLOXL2RAB9ANPC1PTGS1 | |
| SCHEMBL27575328 | 0.81 | SLC7A5 (0.44) | CASRLOXL2RAB9ANPC1PTGS1 | |
| SCHEMBL27679309 | 0.80 | SLC7A5 (0.43) | CASRLOXL2RAB9APTGS1PTGS2 | |
| SCHEMBL20527672 | 0.80 | KDM4D (0.43) | ROCK2CASRLOXL2PTGS1PTGS2 | |
| SCHEMBL8936963 | 0.77 | L3MBTL1 (0.53) | KMT2A | |
| SCHEMBL558157 | 0.77 | TSHR (0.53) | LOXL2RAB9ANPC1CYP4F2CYP4A11 | |
| SCHEMBL3473488 | 0.77 | CTSK (0.45) | CASRLOXL2PTGS1PTGS2CYP4F2 | |
| SCHEMBL15609314 | 0.77 | CTSK (0.45) | CASRLOXL2PTGS1PTGS2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817630-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0817630-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5578629-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996030015-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |