Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8617476 | 0.99 | TSHR (0.56) | TSHRTRPM8HDAC1HDAC6HDAC3 | |
| SCHEMBL8967341 | 0.81 | SLC2A1 (0.54) | TSHRHDAC1HDAC6HDAC3HDAC7 | |
| Hydrochloric Acid SCHEMBL8967290 | 0.80 | SLC2A1 (0.53) | TSHRHDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL1122947 | 0.77 | LPAR1 (0.59) | LPAR1 | |
| SCHEMBL8614121 | 0.75 | ALDH1A1 (0.57) | TSHRHDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL8425714 | 0.74 | HPGDS (0.60) | TSHRHDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL1003508 | 0.74 | HDAC1 (0.71) | TSHRHDAC1HDAC6HDAC3HDAC7 | |
| SCHEMBL5936689 | 0.73 | GAA (0.52) | TSHRLPAR1 | |
| SCHEMBL1122800 | 0.73 | MAPT (0.62) | HDAC1HDAC6L3MBTL1LPAR1 | |
| SCHEMBL8618984 | 0.73 | ALDH1A1 (0.54) | TSHRHDAC1HDAC6HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |