Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9331532 | 0.91 | TBXA2R (0.39) | TBXA2RTSHRATMTBXAS1MAPT | |
| SCHEMBL8797527 | 0.73 | TSHR (0.42) | TBXA2RTSHRTBXAS1MAPTSMN1; SMN2 | |
| SCHEMBL8618759 | 0.73 | TBXA2R (0.40) | TBXA2RTSHRATMTBXAS1MAPT | |
| SCHEMBL8618306 | 0.67 | NR3C1 (0.45) | TBXA2RTBXAS1NR3C1GAAALDH1A1 | |
| SCHEMBL12142430 | 0.66 | HTR2A (0.43) | TBXA2RNR3C1SMN1; SMN2KMT2A | |
| SCHEMBL9088508 | 0.65 | MAPK1 (0.50) | TSHRMAPTGAAALDH1A1MEN1 | |
| SCHEMBL30165132 | 0.64 | MAOB (0.43) | TSHRMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8797397 | 0.63 | ALDH1A1 (0.49) | TBXA2RTBXAS1MAPTGAAALDH1A1 | |
| SCHEMBL7511213 | 0.62 | ALDH1A1 (0.51) | TBXA2RMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8797398 | 0.62 | LPAR1 (0.49) | TBXA2RTSHRMAPTLPAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588608-B1 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0588608-A2 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |