Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617561 | 0.92 | THRB (0.47) | THRATHRBPTGS2TP53ALDH1A1 | |
| SCHEMBL8619949 | 0.90 | THRA (0.45) | THRATHRBPTGS2MAPK1MEN1 | |
| SCHEMBL8618947 | 0.90 | ASF1A (0.42) | THRATHRBSNCAPTGS2SLC22A12 | |
| SCHEMBL8619765 | 0.85 | THRA (0.67) | THRATHRBMAPK1EYA3TP53 | |
| SCHEMBL8763724 | 0.82 | THRA (0.49) | THRATHRBSLC22A12TP53MEN1 | |
| SCHEMBL8624542 | 0.82 | ASF1A (0.44) | THRBSLC22A12TP53ASF1AALDH1A1 | |
| SCHEMBL8624230 | 0.81 | THRA (0.48) | THRATHRBMMP12MAPK1TP53 | |
| SCHEMBL8622612 | 0.80 | THRB (0.37) | THRATHRBSLC22A12TP53ALDH1A1 | |
| SCHEMBL8764634 | 0.79 | NR1H4 (0.45) | THRATHRBSLC22A12MAPK1EYA3 | |
| SCHEMBL8622615 | 0.78 | MAPT (0.40) | THRBMMP12PTGS2SLC22A12TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | claimed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | claimed |
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |