Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655604 | 0.82 | RAB9A (0.62) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL2230478 | 0.80 | RAB9A (0.60) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL111310 | 0.80 | CNR2 (0.53) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL29358323 | 0.80 | CNR2 (0.53) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL25474761 | 0.79 | RAB9A (0.58) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL13306750 | 0.79 | RAB9A (0.58) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL30956107 | 0.79 | RAB9A (0.58) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL4433615 | 0.78 | CNR2 (0.51) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| Naphthalene SCHEMBL10758679 | 0.78 | CNR2 (0.51) | RAB9AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL28198741 | 0.78 | CNR2 (0.51) | RAB9AHDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| US-5416094-A | Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines, medicament containing them, and their use for combating heart failures | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-16 | — | — | US | disclosed |