Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.39 |
| ▸ | GRIK4 | Q16099 | 5/20 | 0.39 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620601 | 0.82 | SIRT2 (0.43) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9749640 | 0.81 | MEN1 (0.43) | SIRT2MAPTGRIK1GRIK2GRIK3 | |
| SCHEMBL8618891 | 0.80 | GRIK1 (0.57) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8619770 | 0.79 | GRIA1 (0.44) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8621754 | 0.76 | ALDH1A1 (0.40) | CYP1A2MAPTHPGDLMNACYP3A4 | |
| SCHEMBL8617971 | 0.74 | SIRT2 (0.40) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| Bicarbonate SCHEMBL8806909 | 0.74 | SIRT2 (0.47) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8621659 | 0.69 | SIRT2 (0.43) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8624831 | 0.68 | SIRT2 (0.40) | SIRT2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8621742 | 0.68 | SIRT2 (0.43) | SIRT2GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| WO-1994025470-A1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |