Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.37 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617954 | 0.82 | SIRT2 (0.43) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL9749646 | 0.81 | KDM4E (0.45) | SIRT2PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL8623646 | 0.80 | GRIK1 (0.54) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8618714 | 0.79 | GRIA1 (0.44) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8622115 | 0.76 | KDM4E (0.41) | KDM4EMYLKALDH1A1HPGD | |
| SCHEMBL8616658 | 0.74 | SIRT2 (0.40) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| Bicarbonate SCHEMBL8807164 | 0.74 | SIRT2 (0.47) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8621736 | 0.69 | SIRT2 (0.43) | SIRT2PARP1GRIK1GRIK2GRIK3 | |
| SCHEMBL8622360 | 0.68 | SIRT2 (0.40) | SIRT2PARP1KDM4EALDH1A1GRIN2D | |
| SCHEMBL8617919 | 0.68 | SIRT2 (0.43) | SIRT2PARP1GRIK1GRIK2GRIK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| WO-1994025470-A1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |