SCHEMBL861808

SCHEMBL861808

CC(C)(C)Cc1cc(Br)c(C(=O)O)s1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 12/20 0.38
GSK3B P49841 1/20 0.36
TSHR P16473 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP2C9 P11712 1/20 0.32
HIF1A Q16665 1/20 0.32
PKM P14618 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
UCHL1 P09936 1/20 0.31
GRN P28799 1/20 0.31
SORT1 Q99523 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22833101 0.80 DAO (0.43) GPR35GSK3BTSHRHSD17B10RXFP1
SCHEMBL25948660 0.76 ALDH1A1 (0.39) GPR35GSK3BTSHRCYP2C9
SCHEMBL1912332 0.73 NPSR1 (0.41) GPR35GSK3BNPSR1RXFP1
SCHEMBL3780362 0.70 GPR35 (0.48) GPR35GSK3BHSD17B10PKMNPSR1
SCHEMBL4264513 0.69 GAA (0.44) HSD17B10CYP2C9HIF1APKMUCHL1
SCHEMBL15878596 0.69 GSK3B (0.61) GPR35GSK3BPKMNPSR1RXFP1
SCHEMBL861282 0.68 LCK (0.40)
SCHEMBL14708715 0.67 NPC1 (0.43) TSHRHSD17B10NPSR1
SCHEMBL432666 0.67 NR1I2 (0.39) GPR35GSK3B
SCHEMBL27416028 0.66 GPR35 (0.40) GPR35GSK3BPKMNPSR1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
WO-2008156879-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION (US) 2008-12-24 WO disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS IK, CRY1, MAP1LC3C GPR35 1942/4885GSK3B 3899/4885TSHR 4444/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.