Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.46 |
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | ARG2 | P78540 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618296 | 0.95 | KMT2A (0.48) | POLBKMT2ATDP1GSRDPP8 | |
| Homoserine SCHEMBL6051437 | 0.88 | KIF11 (0.49) | POLBKMT2ATDP1GSRKIF11 | |
| D-Glutamate SCHEMBL561574 | 0.81 | SLC1A3 (0.64) | POLBKMT2ATDP1GSRKIF11 | |
| Serine SCHEMBL7658418 | 0.81 | ALPI (0.50) | KIF11ALPIPKMPTGS1XIAP | |
| Serine SCHEMBL561331 | 0.81 | ALPI (0.50) | KIF11ALPIPKMPTGS1XIAP | |
| (D)-Serine SCHEMBL6794292 | 0.81 | ALPI (0.50) | KIF11ALPIPKMPTGS1XIAP | |
| SCHEMBL197363 | 0.80 | GSR (0.67) | KMT2AGSRNOS1ARG1ARG2 | |
| SCHEMBL2684333 | 0.80 | GSR (0.67) | KMT2AGSRNOS1ARG1ARG2 | |
| SCHEMBL128663 | 0.80 | GSR (0.67) | KMT2AGSRNOS1ARG1ARG2 | |
| Glutamine SCHEMBL4989095 | 0.80 | KMT2A (0.66) | POLBKMT2ATDP1GSRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710324-A | AMINE CONTAINING COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | disclosed |
| US-5318992-A | Administering for the treatment of hypotensive conditions and shock | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0446699-A1 | Inhibitors of nitric oxide biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-09-18 | — | — | EP | disclosed |