Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620030 | 0.93 | RAB9A (0.60) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL8615161 | 0.92 | RAB9A (0.59) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL8966544 | 0.82 | RAB9A (0.57) | RAB9ASMN1; SMN2NPC1NAMPTKMT2A | |
| SCHEMBL8613525 | 0.77 | RAB9A (0.62) | RAB9ANAMPTKMT2AMEN1USP2 | |
| SCHEMBL8966996 | 0.76 | RAB9A (0.61) | RAB9ANAMPTKMT2AMEN1USP2 | |
| Hydrochloric Acid SCHEMBL8621873 | 0.76 | RAB9A (0.61) | RAB9ANAMPTKMT2AMEN1USP2 | |
| SCHEMBL5092957 | 0.76 | RAB9A (0.72) | RAB9ANAMPTKMT2AMEN1USP2 | |
| SCHEMBL8618256 | 0.75 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL8966304 | 0.75 | RAB9A (0.60) | RAB9ANAMPTKMT2AMEN1USP2 | |
| SCHEMBL19823622 | 0.75 | MEN1 (0.73) | RAB9ASMN1; SMN2NPC1LMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |