SCHEMBL8618972

SCHEMBL8618972

CN(C)c1ccc(-c2cc(-c3cccs3)nc(-c3cccs3)c2)c(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 1/20 0.44
MAPT P10636 6/20 0.42
KDM4E B2RXH2 6/20 0.42
ALDH1A1 P00352 5/20 0.42
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
NFKB1 P19838 2/20 0.42
NFKB2 Q00653 2/20 0.42
RELA Q04206 2/20 0.42
GAA P10253 2/20 0.42
NPC1 O15118 1/20 0.42
HCRTR1 O43613 1/20 0.42
CASP3 P42574 1/20 0.42
RAB9A P51151 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
TDP1 Q9NUW8 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
HPGD P15428 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10977740 0.85 TOP1 (0.45) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL8618790 0.80 MAPT (0.55) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL8621100 0.79 APP (0.42) MAPTKMT2ASMN1; SMN2HPGDLMNA
SCHEMBL11079328 0.75 MAPT (0.60) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL29575458 0.71 KDM4E (0.65) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL10979112 0.70 MAPT (0.55) MAPTKDM4EALDH1A1MEN1KMT2A
SCHEMBL19785366 0.69 ALDH1A1 (0.48) MAPTKDM4EALDH1A1MEN1KMT2A
SCHEMBL14819131 0.69 MAPT (0.47) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL10972792 0.69 KMT2A (0.42) TOP1MAPTKDM4EALDH1A1MEN1
SCHEMBL28171655 0.67 KDM4E (0.61) TOP1MAPTKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4540790-A COLORFORMERS INC PRESSURE SENSITIVE CARBONLESS DUPLICATION THE HILTON-DAVIS CHEMICAL CO. (US) 1985-09-10 US claimed
EP-0061128-B1 PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND SYSTEMS CONTAINING THEM STERLING DRUG INC. (US) 1985-09-04 EP claimed
EP-0061128-A1 Pyridine compounds, process for their preparation and systems containing them STERLING DRUG INC. (US) 1982-09-29 EP claimed
WO-2023085225-A1 METHOD FOR MANUFACTURING RECYCLED RESIN COMPOSITION 住友化学株式会社 2023-05-19 WO disclosed
EP-0659582-B1 Reversible thermochromic composition PILOT INK CO LTD (JP) 1998-05-13 EP disclosed
US-5558700-A QUINAZOLENE OR PYRIDINE ELECTRON DONOR, ELECTRON ACCEPTOR THE PILOT INK CO., LTD. (JP) 1996-09-24 US disclosed
EP-0659582-A1 Reversible thermochromic composition THE PILOT INK CO., LTD. (JP) 1995-06-28 EP disclosed
US-4540790-A COLORFORMERS INC PRESSURE SENSITIVE CARBONLESS DUPLICATION THE HILTON-DAVIS CHEMICAL CO. (US) 1985-09-10 US disclosed
EP-0061128-B1 PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND SYSTEMS CONTAINING THEM STERLING DRUG INC. (US) 1985-09-04 EP disclosed
US-4396767-A COLORS, CARBONLESS DUPLICATION STERLING DRUG INC. (US) 1983-08-02 US disclosed
EP-0061128-A1 Pyridine compounds, process for their preparation and systems containing them STERLING DRUG INC. (US) 1982-09-29 EP disclosed