Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424828 | 0.82 | CYP3A4 (0.44) | HRH4HRH2NAMPTKMT2AMAPT | |
| SCHEMBL9147554 | 0.82 | HRH4 (0.43) | HRH4HRH2NAMPTKMT2AMAPT | |
| SCHEMBL8620026 | 0.81 | HRH4 (0.50) | HRH4HRH2NAMPT | |
| SCHEMBL9148290 | 0.80 | HRH4 (0.41) | HRH4HRH2NAMPTKMT2AMAPT | |
| SCHEMBL9147482 | 0.78 | BCL6 (0.53) | HRH4HRH2NAMPTKMT2AALDH1A1 | |
| SCHEMBL8619800 | 0.77 | HDAC3 (0.35) | HDAC1KMT2AMAPTGAAROCK2 | |
| SCHEMBL8619793 | 0.77 | HDAC3 (0.35) | HDAC1KMT2AMAPTGAAROCK2 | |
| SCHEMBL7354766 | 0.77 | HDAC3 (0.33) | NAMPTHDAC1 | |
| SCHEMBL8619031 | 0.77 | HDAC3 (0.33) | NAMPTHDAC1 | |
| SCHEMBL8619788 | 0.77 | HDAC3 (0.35) | HDAC1KMT2AMAPTGAAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |