SCHEMBL7424828

SCHEMBL7424828

Cc1ccc(NC(=NC#N)NCCCc2ccccc2)cn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.44
CYP2C9 P11712 4/20 0.44
ALDH1A1 P00352 3/20 0.44
CYP2C19 P33261 2/20 0.44
CYP1A2 P05177 1/20 0.44
HRH2 P25021 2/20 0.43
HRH4 Q9H3N8 2/20 0.43
LMNA P02545 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
NAMPT P43490 1/20 0.41
CTDSP1 Q9GZU7 1/20 0.40
MAPT P10636 2/20 0.40
GAA P10253 1/20 0.40
ROCK2 O75116 1/20 0.40
CNR1 P21554 1/20 0.40
KMT2A Q03164 2/20 0.40
KDM4E B2RXH2 1/20 0.40
EPHX1 P07099 1/20 0.40
POLB P06746 1/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9147554 0.87 HRH4 (0.43) CYP3A4CYP2C9ALDH1A1CYP2C19CYP1A2
SCHEMBL9148290 0.86 HRH4 (0.41) CYP3A4CYP2C9ALDH1A1CYP2C19CYP1A2
SCHEMBL9147482 0.84 BCL6 (0.53) CYP3A4ALDH1A1CYP1A2HRH2HRH4
SCHEMBL8620022 0.82 HRH4 (0.40) CYP3A4CYP2C9ALDH1A1CYP2C19CYP1A2
SCHEMBL7359999 0.80 P2RX7 (0.52) CYP3A4CYP2C9ALDH1A1CYP2C19CYP1A2
SCHEMBL17117350 0.79 ALDH1A1 (0.70) CYP3A4CYP2C9ALDH1A1CYP2C19CYP1A2
SCHEMBL7424829 0.78 HRH4 (0.53) HRH2HRH4NAMPT
SCHEMBL7353949 0.77 HRH4 (0.42) HRH2HRH4ROCK2KMT2AKDM4E
SCHEMBL7430606 0.77 POLB (0.53) HRH2HRH4SMN1; SMN2ROCK2CNR1
SCHEMBL9149002 0.77 BCL6 (0.62) CYP3A4CYP1A2HRH4LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741708-A1 CYANOGUANIDINES AS K-CHANNEL BLOCKERS PHARMACIA & UPJOHN COMPANY (US) 1996-11-13 EP disclosed
WO-1995020579-A1 CYANOGUANIDINES AS K-CHANNEL BLOCKERS PHARMACIA & UPJOHN COMPANY (US) 1995-08-03 WO disclosed