Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | THRA | P10827 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | KDM5A | P29375 | 7/20 | 0.36 |
| ▸ | KDM4A | O75164 | 3/20 | 0.36 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.36 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621011 | 0.89 | PTPN1 (0.44) | CYP2C9THRBEYA3TTRABCB11 | |
| SCHEMBL8618898 | 0.84 | THRA (0.55) | CYP2C9THRATHRBKDM5AKDM4A | |
| SCHEMBL8625009 | 0.81 | MMP12 (0.37) | CYP2C9THRATHRBTP53MAPK1 | |
| SCHEMBL8622615 | 0.80 | MAPT (0.40) | THRBLMNAALDH1A1TP53CYP1A2 | |
| SCHEMBL8624484 | 0.74 | PTPN1 (0.47) | CYP2C9THRATHRBKDM5AKDM4A | |
| SCHEMBL8619761 | 0.74 | PTPN1 (0.42) | EYA3LMNAPTPN1MAPK1HTT | |
| SCHEMBL8620047 | 0.72 | THRA (0.39) | CYP2C9THRATHRBEYA3LMNA | |
| SCHEMBL8621631 | 0.70 | THRA (0.52) | CYP2C9THRATHRBKDM5AKDM4A | |
| SCHEMBL8622283 | 0.70 | THRA (0.56) | CYP2C9THRATHRBKDM5AKDM4A | |
| SCHEMBL8618731 | 0.70 | MAPT (0.41) | THRBLMNAPTPN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |