Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618893 | 0.84 | THRA (0.56) | THRATHRBALDH1A1LMNACYP2C9 | |
| SCHEMBL8621007 | 0.84 | NR1H4 (0.36) | THRATHRBKDM4ELOXL2NR1H4 | |
| SCHEMBL8625007 | 0.82 | THRB (0.34) | THRATHRB | |
| SCHEMBL8622612 | 0.81 | THRB (0.37) | THRATHRBKDM4EALDH1A1SLC22A12 | |
| SCHEMBL8621630 | 0.72 | THRA (0.53) | THRATHRBALDH1A1LMNACYP2C9 | |
| SCHEMBL8620052 | 0.72 | CYP2C9 (0.38) | THRATHRBALDH1A1LMNACYP2C9 | |
| SCHEMBL8619759 | 0.71 | HTT (0.35) | THRATHRBKDM4ENR1H4LMNA | |
| SCHEMBL8622283 | 0.70 | THRA (0.56) | THRATHRBALDH1A1LMNACYP2C9 | |
| SCHEMBL8624478 | 0.70 | THRB (0.43) | THRATHRBNR1H4ALDH1A1HPGD | |
| SCHEMBL8624397 | 0.70 | THRA (0.49) | THRATHRBALDH1A1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |