Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.44 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | EYA2 | O00167 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621011 | 0.86 | PTPN1 (0.44) | PTPN1CYP2C19TTRSLC22A12EYA3 | |
| SCHEMBL8618898 | 0.83 | THRA (0.55) | EYA3SIRT3CYP2C9THRBMEN1 | |
| SCHEMBL8621571 | 0.81 | TTR (0.48) | PTPN1CYP2C19TTRSLC22A12EYA3 | |
| SCHEMBL8620718 | 0.76 | SLC22A12 (0.45) | TTRSLC22A12ABCB11ESR1PGR | |
| SCHEMBL8620052 | 0.74 | CYP2C9 (0.38) | PTPN1TTREYA3SIRT3CYP2C9 | |
| SCHEMBL6336688 | 0.74 | PTPN1 (0.70) | PTPN1CYP2C19TTREYA3NR1H4 | |
| SCHEMBL6336686 | 0.74 | PTPN1 (0.70) | PTPN1CYP2C19TTREYA3NR1H4 | |
| SCHEMBL8619761 | 0.72 | PTPN1 (0.42) | PTPN1CYP2C19SLC22A12EYA3NR1H4 | |
| SCHEMBL8624478 | 0.71 | THRB (0.43) | PTPN1CYP2C19TTRSLC22A12EYA3 | |
| SCHEMBL8621631 | 0.70 | THRA (0.52) | EYA3SIRT3CYP2C9THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |