Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | FABP7 | O15540 | 2/20 | 0.46 |
| ▸ | FABP3 | P05413 | 2/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947116 | 0.87 | ALDH1A1 (0.51) | PRKCIPRKCZSMN1; SMN2KDM4ETP53 | |
| SCHEMBL7533246 | 0.87 | FABP7 (0.54) | FABP7FABP3FABP5SCD5EDNRA | |
| SCHEMBL8623769 | 0.87 | EDNRA (0.49) | PRKCIPRKCZEDNRAEDNRBALDH1A1 | |
| SCHEMBL8625505 | 0.86 | PRKCI (0.47) | PRKCIPRKCZSMN1; SMN2KDM4ETP53 | |
| SCHEMBL8621789 | 0.85 | ABCB1 (0.46) | PRKCIPRKCZSCD5EDNRAMGAM | |
| SCHEMBL8622121 | 0.81 | ALDH1A1 (0.51) | PRKCIPRKCZTP53HSD17B10MGAM | |
| SCHEMBL8678051 | 0.78 | EDNRA (0.52) | SMN1; SMN2EDNRAEDNRBALDH1A1 | |
| SCHEMBL8620562 | 0.77 | FABP7 (0.52) | FABP7FABP3FABP5SCD5EDNRA | |
| SCHEMBL8620432 | 0.76 | EDNRA (0.51) | PRKCIPRKCZSMN1; SMN2KDM4ETP53 | |
| SCHEMBL7531484 | 0.73 | EDNRA (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |