Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.49 |
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947116 | 0.91 | ALDH1A1 (0.51) | ALDH1A1PRKCIPRKCZ | |
| SCHEMBL8621789 | 0.91 | ABCB1 (0.46) | EDNRAEDNRBALDH1A1TDP1PRKCI | |
| SCHEMBL8625505 | 0.90 | PRKCI (0.47) | ALDH1A1PRKCIPRKCZ | |
| SCHEMBL8678051 | 0.90 | EDNRA (0.52) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL7531484 | 0.88 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8620561 | 0.87 | PRKCI (0.48) | EDNRAEDNRBALDH1A1PRKCIPRKCZ | |
| SCHEMBL8622121 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TDP1PRKCIPRKCZ | |
| SCHEMBL8620425 | 0.83 | ALDH1A1 (0.54) | ALDH1A1TDP1 | |
| SCHEMBL8626850 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1 | |
| SCHEMBL7531670 | 0.78 | FABP7 (0.49) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |