Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797337 | 0.83 | ALDH1A1 (0.42) | TBXA2RALDH1A1MAPTAKR1B1TBXAS1 | |
| SCHEMBL8615765 | 0.76 | AKR1B1 (0.45) | TBXA2RAKR1B1TBXAS1HTR2AHTR2C | |
| SCHEMBL8617506 | 0.76 | TBXA2R (0.46) | TBXA2RAKR1B1TBXAS1HTR2AHTR2C | |
| SCHEMBL8617465 | 0.76 | TBXA2R (0.46) | TBXA2RAKR1B1TBXAS1 | |
| SCHEMBL8797282 | 0.75 | TP53 (0.44) | ALDH1A1MAPT | |
| SCHEMBL8799249 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPTHTR2AHTR2CHRH1 | |
| SCHEMBL8797278 | 0.74 | TP53 (0.41) | ALDH1A1MAPT | |
| SCHEMBL8797543 | 0.72 | TP53 (0.39) | ALDH1A1MAPT | |
| SCHEMBL8797294 | 0.71 | TP53 (0.38) | TBXA2RALDH1A1MAPT | |
| SCHEMBL8614670 | 0.71 | TBXA2R (0.47) | TBXA2RALDH1A1MAPTTBXAS1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588608-B1 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0588608-A2 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |