Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797278 | 0.87 | TP53 (0.41) | TP53NLRP3MAPTALDH1A1TDP1 | |
| SCHEMBL8797254 | 0.86 | NLRP3 (0.36) | TP53NLRP3MAPTALDH1A1LMNA | |
| SCHEMBL8797616 | 0.82 | TP53 (0.39) | TP53NLRP3MAPTTDP1ROCK2 | |
| SCHEMBL8797282 | 0.77 | TP53 (0.44) | TP53MAPTALDH1A1HTTRAB9A | |
| SCHEMBL8797337 | 0.75 | ALDH1A1 (0.42) | MAPTALDH1A1TBXA2R | |
| SCHEMBL8797543 | 0.74 | TP53 (0.39) | TP53NLRP3MAPTALDH1A1TDP1 | |
| SCHEMBL8798136 | 0.72 | TP53 (0.42) | TP53NLRP3ALDH1A1LMNAKMT2A | |
| SCHEMBL8798200 | 0.72 | TP53 (0.48) | TP53MAPTTDP1ROCK2HTT | |
| SCHEMBL8620574 | 0.71 | TBXA2R (0.40) | MAPTALDH1A1TBXA2R | |
| SCHEMBL8797534 | 0.71 | NLRP3 (0.39) | TP53NLRP3ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | claimed |