Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8620664 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL5799074 | 0.93 | TSHR (0.60) | — | |
| Fumaric Acid SCHEMBL3742400 | 0.93 | TSHR (0.60) | — | |
| Maleic Acid SCHEMBL8163405 | 0.93 | TSHR (0.60) | — | |
| Fumaric Acid SCHEMBL106909 | 0.93 | — | — | |
| Fumaric Acid SCHEMBL5816 | 0.93 | — | — | |
| Fumaric Acid SCHEMBL5819 | 0.93 | — | — | |
| Fumaric Acid SCHEMBL106910 | 0.93 | — | — | |
| Fumaric Acid SCHEMBL106606 | 0.93 | — | — | |
| Fumaric Acid SCHEMBL263298 | 0.93 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543340-B1 | Process for preparing lactones | TOSOH CORP (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5502217-A | MULTISTAGE PROCESS WITH HYDROGENATION OF MALEIC ACID OR SUCCINIC ACID IN THE PRESENCE OF METAL TO FORM BUTYROLACTONE | TOSOH CORPORATION (JP) | 1996-03-26 | — | — | US | disclosed |
| EP-0543340-A1 | Process for preparing lactones | Tosoh Corporation (JP) | 1993-05-26 | — | — | EP | disclosed |