Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | ACACA | Q13085 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8615321 | 0.90 | PDE10A (0.54) | ALDH1A1POLBPDE10ACCR6ACACA | |
| SCHEMBL8617709 | 0.89 | PDE10A (0.69) | ALDH1A1POLBPDE10ACCR6ACACA | |
| SCHEMBL8617400 | 0.87 | MEN1 (0.46) | ALDH1A1POLBMEN1KMT2AGAA | |
| SCHEMBL8615931 | 0.87 | PDE10A (0.51) | ALDH1A1POLBPDE10ACCR6ACACA | |
| SCHEMBL8617941 | 0.85 | PDE10A (0.64) | ALDH1A1POLBPDE10AACACAMEN1 | |
| SCHEMBL8615313 | 0.84 | PDE10A (0.54) | ALDH1A1PDE10ACCR6ACACAMEN1 | |
| SCHEMBL8618650 | 0.84 | LMNA (0.47) | ALDH1A1POLBPDE10AMEN1KMT2A | |
| SCHEMBL28184818 | 0.84 | PDE10A (0.75) | ALDH1A1POLBPDE10ACCR6ACACA | |
| SCHEMBL8613763 | 0.83 | TACR3 (0.46) | ALDH1A1PDE10ACCR6MEN1KMT2A | |
| SCHEMBL8613481 | 0.83 | KDM4E (0.56) | ALDH1A1POLBPDE10ACCR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |