Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622359 | 0.93 | SIRT2 (0.39) | SIRT2LMNAMAPTHPGDKMT2A | |
| SCHEMBL8624831 | 0.89 | SIRT2 (0.40) | SIRT2LMNAMAPTHPGDKMT2A | |
| SCHEMBL8624320 | 0.88 | SIRT2 (0.35) | SIRT2ALDH1A1GAALMNAMAPT | |
| SCHEMBL8621742 | 0.82 | SIRT2 (0.43) | SIRT2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL9036662 | 0.82 | SIRT2 (0.31) | SIRT2ALDH1A1GAALMNAMAPT | |
| SCHEMBL8616755 | 0.81 | SIRT2 (0.37) | SIRT2LMNAMAPTHPGDGRIN2D | |
| SCHEMBL8619987 | 0.79 | SIRT2 (0.38) | SIRT2LMNAMAPTHPGDGRIN2D | |
| SCHEMBL8619832 | 0.79 | SIRT2 (0.41) | SIRT2LMNAMAPTHPGDKMT2A | |
| SCHEMBL8617993 | 0.78 | SIRT2 (0.39) | SIRT2ALDH1A1GAALMNAMAPT | |
| SCHEMBL9749640 | 0.76 | MEN1 (0.43) | SIRT2ALDH1A1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | disclosed |