SCHEMBL8621202

SCHEMBL8621202

C[SiH](C)CCCc1cccc(Oc2ccccc2)c1F

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 1/20 0.43
SLC6A4 P31645 7/20 0.42
SLC6A2 P23975 5/20 0.42
RIPK1 Q13546 1/20 0.42
HTR2A P28223 2/20 0.40
SLC6A3 Q01959 4/20 0.38
LPAR1 Q92633 1/20 0.36
LPAR5 Q9H1C0 1/20 0.36
DPP4 P27487 1/20 0.35
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
FFAR1 O14842 1/20 0.33
BCL2L2 Q92843 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22185409 0.80 SLC6A4 (0.50) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL10548587 0.77 RIPK1 (0.46) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL13687729 0.75 HRH1 (0.58) HRH1SLC6A4SLC6A2RIPK1HTR2A
Hydrochloric Acid SCHEMBL921538 0.73 HRH1 (0.56) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL11387994 0.73 HRH1 (0.47) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL6547524 0.73 TTR (0.40) LPAR1LPAR5
SCHEMBL10548505 0.73 RIPK1 (0.42) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL10548364 0.72 RIPK1 (0.40) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL6290359 0.71 AR (0.45) HRH1SLC6A4SLC6A2RIPK1HTR2A
SCHEMBL27854361 0.70 CXCL8 (0.58) HRH1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842019-A1 PROTECTIVE WOOD PRESERVATIVES Rütgers Organics GmbH (DE) 1998-05-20 EP claimed
WO-1997002119-A1 PROTECTIVE WOOD PRESERVATIVES RÜTGERS ORGANICS GMBH (DE) 1997-01-23 WO claimed
EP-0842019-A1 PROTECTIVE WOOD PRESERVATIVES Rütgers Organics GmbH (DE) 1998-05-20 EP disclosed
WO-1997002119-A1 PROTECTIVE WOOD PRESERVATIVES RÜTGERS ORGANICS GMBH (DE) 1997-01-23 WO disclosed