Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.40 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621631 | 0.90 | THRA (0.52) | SIRT3THRATHRBEYA3KDM4A | |
| SCHEMBL8619761 | 0.85 | PTPN1 (0.42) | PTPN1EYA3CYP2C19NR1H4SLC22A12 | |
| SCHEMBL8619555 | 0.84 | TTR (0.69) | TTRSIRT3PTPN1THRATHRB | |
| SCHEMBL8624484 | 0.81 | PTPN1 (0.47) | TTRSIRT3PTPN1THRATHRB | |
| SCHEMBL4891172 | 0.80 | EYA3 (0.57) | TTRSIRT3PTPN1THRATHRB | |
| SCHEMBL8620718 | 0.79 | SLC22A12 (0.45) | TTRSLC22A12 | |
| SCHEMBL4274820 | 0.77 | CA12 (0.48) | TTRPTPN1EYA3 | |
| SCHEMBL6336686 | 0.77 | PTPN1 (0.70) | TTRSIRT3PTPN1THRATHRB | |
| SCHEMBL6336688 | 0.77 | PTPN1 (0.70) | TTRSIRT3PTPN1THRATHRB | |
| SCHEMBL8618726 | 0.77 | EYA3 (0.68) | TTRSIRT3PTPN1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |